Production of Conductive Biocompatible Nanofibrous Substrate made of PLGA/PCL/PANI

Document Type : Research Article

Authors

1 Hazrate Masoumeh University, Qom

2 Department of Textile Engineering, Amirkabir University of Technology, Tehran

/amnc.2017.6.22.5

Abstract

Due to the high utilization of conductive materials as well as nanofibrous substrates in various engineering and sciences such as tissue engineering, biosensors, etc., in this study production of conductive biocompatible nanofibrous substrates using electrospinning system was studied. For this purpose, the combination of two biocompatible polymers: polycaprolactone (PCL) and poly(lactic-co-glycolic acid) (PLGA) was used as a main material and polyaniline as a conductive polymer (PANI) to create conductivity in the substrates. After determining the properties of electrospun substrates and optimization of process factors, 4 types of nanofibrous substrate with 4 level of conductive polymer (0%, 1%, 10% & 18%) were prepared.
Investigating the physical properties of substrates show that with increasing the amount of PANI, hydrophilicity of the substrates as well as the diameter of the fibers decreased significantly. Furthermore, the conductivity of samples gradually increased from 0.17 to 0.32 S/cm*10-4 by elevating the PANI concentration.

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References

[1]      Zamani, F., Post Postdoctoral Thesis. Tehran: Amirkabir University of Technology. 2014.
[2]      Tabesh, H., Amoabediny, Gh., Salehi Nik, N., " The role of biodegradable engineered scaffolds seeded with Schwann cells for spinal cord regeneration", Neurochemistry International, vol. 54, pp.73–83, 2009.
[3]      Yuan, X., Zhang, Y., Dong, C., Sheng, J., “Morphology of ultrafine polysulfone fibers prepared by electrospinning”, Polymer International, Vol. 53, pp. 1704-1710, 2004.
[4]      Ghasemi-Mobarakeh, L., Prabhakaran, M., Morshed, M., "Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering", J Tissue Eng Regen Med, Vol. 5, pp. 17-35, 2011.
[5]      Schmidt, C.E., Shastri, V.R.,"Stimulation of neurite outgrowth using an electrically conducting polymer", Applied Biological Sciences,Vol. 94, pp. 8948–8953, 1997.
[6]      Shi G., Rouabhia M., Meng S., Zhang Z.," Electrical stimulation enhances viability of human cutaneous fibroblasts on conductive biodegradable substrates", J. Biomedical Materials Research: Part A., Vol. 84A, pp. 1026-1037, 2007.
[7]      Cong, Y., Liu, S., Chen, H.,"Fabrication of Conductive Polypyrrole Nanofibers by Electrospinning", Journal of Nanomaterials, pp. 1-6,  2013.
[8]      Hopkins AR., Rasmussen PG., "Characterization of Solution and Solid State Properties of Undoped and Doped Polyanilines Processed from Hexafluoro-2-propanol", Macromolecules., Vol. 29, pp. 7838-7846, 1996.
[9]      Li, M., Guo. Y., "Electrospinning Polyaniline-Contained gelatine nanofibers for tissue engineering applications", Biomaterials, vol. 27, pp. 2705–2715, 2006.
[10]   Lee, J.Y.,"Electrically Conducting Polymer Based Nanofibrous Scaffolds for Tissue Engineering Applications", Polymer Reviews, Vol. 53, pp. 443–459, 2013.
[11]  Laska J., "Conformayions of Polyaniline in Polymer blends", J. Molecular Structure., Vol. 701, pp. 13-18, 2004.
[12]  Yanılmaz, M. and Sarac, A.S., “A review: effect of conductive polymers on the conductivities of electrospun mats”. Textile Research Journal, 2014. 84(12): p. 1325-1342.
[13]  Zamani, F., Amani-Tehran, M., Latifi, M., Shokrgozar, MA., "The influence of surface nanoroughness of electrospun PLGA nanofibrous scaffold on nerve cell adhesion and proliferation", J Mater Sci, Mater Med, vol. 24, pp. 1551–1560, 2013.
[14]  Zamani, F., Amani-Tehran, M., Latifi, M., Shokrgozar, MA., Zaminy, A., "Promotion of spinal cord axon regeneration by 3D nanofibrous core–sheath scaffolds", J Biomed Mater Res Part A, vol. 102, pp. 506–513, 2014.
[15]  Jahanmard, F., Amani-Tehran, M., Zamani, F., "Effect of Nanoporous Fibers on Growth and Proliferation of Cells on Electrospun Poly (ϵ-caprolactone) Scaffolds", Int Poly Mat & Poly Biomat, vol. 63, pp. 57–64, 2013.
[16]   Subramanian, S., Krishnan, UM., "Fabrication, Characterization and In Vitro Evaluation of Aligned PLGA–PCL Nanofibers for Neural Regeneration", Annals of Biomedical Engineering, Vol. 40, No. 10, pp. 2098–2110, 2012.
[17]  Yang A, Huang Z, Yin G, Pu X, Fabrication of aligned, porous and conductive fibers and their effects on cell adhesion and guidance, Colloid Surf. B, Biointerfaces, 134, 2015, 469-474.
[18]  Zamani, F., Latifi, M., Amani-Tehran, M., Shokrgozar, MA., "Effects of PLGA Nanofibrous Scaffolds Structure on Nerve Cell Directional Proliferation and Morphology", Fiber Polym, vo. 14, pp. 568–702, 2013.

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