Tungstate sulfuric acid: a highly efficient catalyst in solvent-free multi-component reactions

Document Type : Research Article

Authors
Mehrdad Cheraghi 1
Bahador Karami 2
Mahnaz Farahi 3
Mosadegh Keshavarz 4
Shadpour Mallakpour 5
1 Department of chemistry, Yasouj University, Yasouj Iran
2 Department of chemistry, Yasouj University, Yasouj , Iran
3 Department of chemistry, Yasouj University, Iran
4 Department of Applied Chemistry, Yasouj University,
5 Faculty of Chemistry, , Isfahan University of Technology, Isfahan, Iran
amnc.2022.10.40.4
Abstract
The green synthesis of 2H-indazolo[2,1-b] phthalazine-triones, as a group of phthalazine derivatives, and triazolo[1,2-a]indazole-triones, as a group of urazole derivatives by employing three-component condensation of aldehydes and dimedone with a phthalhydrazide or N-phenylurazole is an actively growing area in organic synthesis. A simple, ecofriendly method based on using tungstate sulfuric acid (TSA), as a highly efficient catalyst, is proposed for the one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-trione and triazolo[1,2-a]indazole-trione derivatives by the three-component condensation reaction of 4-phenylurazole or phthalhydrazide, dimedone, and various aromatic aldehydes under solvent-free conditions in excellent yields and very short reaction times. It was found that low amount of the catalysts is optimized amount to achieve desired products in short times (5-10 min) with high isolated yields (90-95%). Some superiorities of the introduced catalysts are their novelty, simple separation and their reusability up to six repeated runs without significant catalytic deactivation. principals such as green conditions, straightforward processes without any byproduct, no need for expensive, time consuming and tedious extraction or purification techniques which could make this catalyst favorable and superior catalysts for organic transformations.
Keywords
Multi-component reaction
Tungstate sulfuric acid
4-Phenylurazole
Phthalhydrazide
Solvent-free
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