Kinetic study of ß-carotene degradation in nanostructured lipid carriers

Document Type : Research Article

Authors

1 Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran

2 Department of Organic Colorants, Institute for Color Science and Technology (ICST), Tehran, Iran

/amnc.2019.8.29.6

Abstract

In this research, degradation of ß-carotene in nanostructured lipid carriers was studied employing spectrophotometric method. The effect of ß-carotene concentration, liquid lipid concentration, surfactant concentration and temperature on stability of ß-carotene was investigated. ß-carotene loaded nanostructured lipid carriers were prepared using solvent diffusion method and the samples were kept in darkness at room temperature. The results indicated that the degradation of ß-carotene in nanostructured lipid carriers follows first order kinetics. The stability of ß-carotene increased significantly by increasing the liquid oil concentration. Furthermore, rising the ß-carotene and surfactant concentrations from 1-5 %w/w resulted in climbing of degradation rate constants from 0.00473 and 0.00737 up to 0.01280 and 0.01093 1/h, respectively. ß-carotene retention decreased by Increment of temperature from 5°C to 65°C while further elevating of temperature was led to reverse results. Particle size studies revealed that addition of ß-carotene to nanostructured lipid carriers grows particle size from 38nm to 105 nm. Moreover, liquid lipid concentration had no significant effect on initial particle size of ß-carotene loaded nanostructured lipid carrier.

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References

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